the reporting odds ratio and its advantages over proportional reporting ratio

Summary The PRR is similar to the proportional mortality ratio (PMR), an old epidemiologic measure calculated from death registries and constructed in similar fashion to the PRR. The PMR has important deficiencies, however, which the PRR shares. Miettinen and Wang demonstrated that the PMR could be improved by reformulating it as an odds ratio and applying the principles of a case-control study to the measure. Introduction Calculation of a risk different or risk ratio is simple in clinical trials, but trials are seldom useful for assessing the risk of rare adverse events. 在臨床試驗中要計算AR與RR是很簡單的，可是以臨床試驗來評估罕見不良事件發生的風險，卻難以達到我們預期的成果。因此，由製藥廠還有主管機關所提供的一般族群資料，特別是自願的不良事件報告(spontaneous reports of adverse events)，就變成用藥安全監控一個很重要的資料來源。而 A problem with the PRR Analogy with the PMR The MOR and the ROR Discussion References Review The Words Adverse adjective not likely to produce a good result This drug is known to have adverse side effects. rigorous adjective done carefully and with a lot of attention to detail thorough a rigorous analysis/investigation magnitude noun the degree to which something is large or important ~ of someting We did not realize the magnitude of the problem. scrutiny noun careful and thorough examination. Foreign policy has come under close scrutiny recently. cardinal adjective most important; having other things based on it Respect for life is a cardinal principle of English law. notoriety noun fame for being bad in some way He gained a certain notoriety as a gambler. mitigate verb to make something less harmful, serious, etc. Soil erosion was mitigated by the planting of trees. spontaneous adjective not planned but done because you suddenly want to do it. a spontaneous offer of help

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